Hypertonic saline for cerebral edema

被引:13
作者
Alexandros L. Georgiadis
Josè I. Suarez
机构
[1] Department of Neurology, University Hospitals of Cleveland, Cleveland, OH 44106
关键词
Traumatic Brain Injury; Cerebral Blood Flow; Cerebral Edema; Intracranial Hypertension; Hypertonic Saline;
D O I
10.1007/s11910-003-0058-1
中图分类号
学科分类号
摘要
Raised intracranial pressure (ICP) is a major contributor to the mortality of many conditions encountered in a neurologic intensive care unit. Achieving a sustained reduction in ICP in patients with intracranial hypertension remains a challenge. Treatment with hyperosmolar agents is one of the few options that are available, and mannitol is currently the most commonly used agent. However, hypertonic saline solutions have recently emerged as a potentially safer and more efficacious alternative to mannitol. Copyright © 2003 by Current Science Inc.
引用
收藏
页码:524 / 530
页数:6
相关论文
共 44 条
[1]  
Bingaman W.E., Frank J.I., Malignant cerebral edema and intracranial hypertension, Neurol. Clin., 13, pp. 479-509, (1995)
[2]  
Smith H.P., Kelly D.L., McWhorter J.M., Et al., Comparisons of mannitol regimens in patients with severe head injury undergoing intracranial monitoring, J. Neurosurg., 65, pp. 820-824, (1986)
[3]  
Schwartz M.L., Tator C.H., Rowed D.W., Et al., The University of Toronto head injury treatment study: A prospective, randomized comparison of pentobarbital and mannitol, Can. J. Neurol. Sci., 11, pp. 434-440, (1984)
[4]  
Lang E.W., Chestnut R.M., Intracranial pressure: Monitoring and management, Neurosurg. Clin. North Am., 5, pp. 573-605, (1994)
[5]  
Fishman R.A., Blood-brain barrier, Cerebrospinal Fluid in Diseases of the Nervous System, pp. 43-69, (1992)
[6]  
Swanson P.D., Neurological manifestations of hypernatremia, Handbook of Clinical Neurology, Volume 28: Metabolic and Deficiency Diseases of the Nervous System, PART II, pp. 443-461, (1976)
[7]  
Fishman R.A., Brain edema, N. Engl. J. Med., 293, pp. 706-711, (1975)
[8]  
Fishman R.A., Intracranial pressure: Physiology and pathophysiology, Cerebrospinal Fluid in Diseases of the Nervous System, 1992, pp. 71-101
[9]  
Tseng M.Y., Al-Rawi P.G., Pickard J.D., Et al., Effect of hypertonic saline on cerebral blood flow in poor-grade patients with subarachnoid hemorrhage, Stroke, 34, pp. 1389-1397, (2003)
[10]  
Muizelaar J.P., Wei E.P., Kontos H.A., Becker D.P., Cerebral blood flow is regulated by changes in blood pressure and blood viscosity alike, Stroke, 17, pp. 44-48, (1986)