Partitioning heritability by functional annotation using genome-wide association summary statistics

被引：0

作者：

Hilary K Finucane

Brendan Bulik-Sullivan

Alexander Gusev

Gosia Trynka

Yakir Reshef

Po-Ru Loh

Verneri Anttila

Han Xu

Chongzhi Zang

Kyle Farh

Stephan Ripke

Felix R Day

Shaun Purcell

Eli Stahl

Sara Lindstrom

John R B Perry

Yukinori Okada

Soumya Raychaudhuri

Mark J Daly

Nick Patterson

Benjamin M Neale

Alkes L Price

机构：

[1] Massachusetts Institute of Technology,Department of Mathematics

[2] Harvard T.H. Chan School of Public Health,Department of Epidemiology

[3] Analytic and Translational Genetics Unit,Division of Genetics

[4] Massachusetts General Hospital and Harvard Medical School,Division of Rheumatology

[5] Stanley Center for Psychiatric Research,Department of Computer Science

[6] Broad Institute of MIT and Harvard,Department of Biostatistics and Computational Biology

[7] Brigham and Women's Hospital,Department of Psychiatry

[8] Harvard Medical School,Department of Human Genetics and Disease Diversity

[9] Brigham and Women's Hospital,undefined

[10] Harvard Medical School,undefined

[11] Partners Center for Personalized Genetic Medicine,undefined

[12] Program in Medical and Population Genetics,undefined

[13] Broad Institute of MIT and Harvard,undefined

[14] Wellcome Trust Sanger Institute,undefined

[15] Wellcome Trust Genome Campus,undefined

[16] Harvard University,undefined

[17] Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health,undefined

[18] Epigenomics Program,undefined

[19] Broad Institute of MIT and Harvard,undefined

[20] Medical Research Council (MRC) Epidemiology Unit,undefined

[21] University of Cambridge School of Clinical Medicine,undefined

[22] Institute of Metabolic Science,undefined

[23] Cambridge Biomedical Campus,undefined

[24] Mount Sinai School of Medicine,undefined

[25] Graduate School of Medical and Dental Sciences,undefined

[26] Tokyo Medical and Dental University,undefined

[27] Laboratory for Statistical Analysis,undefined

[28] RIKEN Center for Integrative Medical Sciences,undefined

[29] Faculty of Medical and Human Sciences,undefined

[30] University of Manchester,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Hilary Finucane, Brendan Bulik-Sullivan, Benjamin Neale, Alkes Price and colleagues introduce a new method, called stratified LD score regression, for partitioning heritability by functional category using genome-wide association study summary statistics. They observe a substantial enrichment of heritability in conserved regions and illustrate how this approach can provide insights into the biological basis of disease and direction for functional follow-up.

引用

页码：1228 / 1235

页数：7

共 50 条

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Gusev, Alexander
Trynka, Gosia
Reshef, Yakir
Loh, Po-Ru
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Ripke, Stephan
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