Effect of Sulforaphane on NOD2 via NF-κB: implications for Crohn’s disease

[1] Ogura Y(2001)Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB J Biol Chem 276 4812-8

[2] Inohara N(2006)Signalling pathways and molecular interactions of NOD1 and NOD2 Nat Rev Immunol 6 9-20

[3] Benito A(2003)Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection J Biol Chem 278 8869-72

[4] Chen FF(2010)The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis Mucosal Immunol 3 17-28

[5] Yamaoka S(2003)NODs: intracellular proteins involved in inflammation and apoptosis Nat Rev Immunol 3 371-82

[6] Nunez G(2009)Inflammatory bowel disease N Engl J Med 361 2066-78

[7] Strober W(2001)Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 411 599-603

[8] Murray PJ(2001)A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Nature 411 603-6

[9] Kitani A(2010)The protein Nod2: an innate receptor more complex than previously assumed Biochem Pharmacol 80 2021-31

[10] Watanabe T(2010)NOD2-associated diseases: Bridging innate immunity and autoinflammation Clin Immunol 134 251-61

[1] Ogura Y(2001)Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB J Biol Chem 276 4812-8

[2] Inohara N(2006)Signalling pathways and molecular interactions of NOD1 and NOD2 Nat Rev Immunol 6 9-20

[3] Benito A(2003)Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection J Biol Chem 278 8869-72

[4] Chen FF(2010)The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis Mucosal Immunol 3 17-28

[5] Yamaoka S(2003)NODs: intracellular proteins involved in inflammation and apoptosis Nat Rev Immunol 3 371-82

[6] Nunez G(2009)Inflammatory bowel disease N Engl J Med 361 2066-78

[7] Strober W(2001)Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 411 599-603

[8] Murray PJ(2001)A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Nature 411 603-6

[9] Kitani A(2010)The protein Nod2: an innate receptor more complex than previously assumed Biochem Pharmacol 80 2021-31

[10] Watanabe T(2010)NOD2-associated diseases: Bridging innate immunity and autoinflammation Clin Immunol 134 251-61