Dynamic responses of the haematopoietic stem cell niche to diverse stresses

被引：0
|
作者：
Antoniana Batsivari
Myriam Luydmila Rachelle Haltalli
Diana Passaro
Constandina Pospori
Cristina Lo Celso
Dominique Bonnet
机构：
[1] The Francis Crick Institute ,Haematopoietic Stem Cell Laboratory
[2] South Kensington campus,Department of Life Sciences, Imperial College London
[3] The Francis Crick Institute,Lo Celso Laboratory
来源：
Nature Cell Biology | 2020年 / 22卷
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摘要：
Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal and haematopoietic cells regulate their function. The steady state HSC niche has been extensively studied. In this Review, we focus on how bone marrow microenvironment components respond to different insults including inflammation, malignant haematopoiesis and chemotherapy. We highlight common and unique patterns among multiple cell types and their environment and discuss current limitations in our understanding of this complex and dynamic tissue.
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页码：7 / 17
页数：10
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