Diagnosis of diabetes mellitus in cystic fibrosis (CF) - Role of blood sugar, HbA(1c) and oral glucose test

被引：4

作者：

Buck C. ^{[1
]}

Thon A. ^{[1
]}

Wolf A. ^{[1
]}

Kohne E. ^{[1
]}

Holl R.W. ^{[1
]}

机构：

[1] 89134 Blaustein

来源：

Monatsschrift Kinderheilkunde | 2000年 / 148卷 / 7期

关键词：

Cystic fibrosis; Diabetes mellitus; HbA(1c); Oral glucose tolerance test;

D O I：

10.1007/s001120050623

中图分类号：

学科分类号：

摘要：

Background. With increasing age and prolonged life expectancy a higher incidence and prevalence of diabetes mellitus is found in patients with CF. An early diagnosis of diabetes mellitus is important, since CF-patients with diabetes mellitus present with worse clinical status and increased mortality. Method. An examination of fasting blood glucose, HbA(1c) level and oral glucose tolerance test were performed in 102 CF-patients during routine care. The values of oral glucose tolerance testing (2 hr blood glucose level) were interpreted according to WHO criteria. In addition the new classification of the American Diabetes Association (ADA) was used, based on fasting blood glucose level. Results. 65,7% of CF-patients had normal glucose tolerance, 21,6% had impaired glucose tolerance and in 12,7% of patients diabetes mellitus was diagnosed based on a 2 hr-blood glucose level >200 mg/dl. None of the CF patients had clinical symptoms typical for diabetes. None of the CF-patients had fasting blood sugar levels above 126 mg/dl which alone defines diabetes mellitus according to the new ADA classification. Mean values of fasting blood glucose in CF-patients with diabetes were not statistically different from CF-patients with normal glucose tolerance (p=0,27).4% of CF-patients with normal glucose tolerance and 23% of patients with impaired glucose tolerance had elevated HbA(1c) levels. However the sensitivity of HbA(1c) was low, since only 23% of CF-Patients with diabetes mellitus displayed elevated HbA(1c). Conclusion. An early diagnosis of diabetes mellitus was only possible by performing an oral glucose tolerance test. Clinical symptoms, fasting blood glucose and HbA(1c) value were not sensitive to diagnose CF related diabetes mellitus. We therefore suggest to perform a standardized oral glucose tolerance test once a year in all CF- patients older than 8 years.

引用

页码：698 / 701

页数：3

共 21 条

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