1H-NMR metabolic profiling of human neonatal urine

被引:0
作者
S. Trump
S. Laudi
N. Unruh
R. Goelz
D. Leibfritz
机构
[1] University of Colorado at Denver and Health Sciences Center,Department of Anesthesiology
[2] University of Leipzig Medical Faculty,Department of Anesthesiology and Intensive Care Medicine
[3] University Children’s Hospital Department IV,Institute of Organic Chemistry FB2/Chemistry
[4] Universität Bremen,undefined
来源
Magnetic Resonance Materials in Physics, Biology and Medicine | 2006年 / 19卷
关键词
Magnetic resonance spectroscopy; Urine; Neonate; Metabolites;
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中图分类号
学科分类号
摘要
Object: The measurement of different urine components and their changes over time may provide comprehensive and early information about perinatal metabolic processes and physiological changes. We hypothesized that 1H−NMR-spectroscopy generating a complex spectral profile without pre-selection of urinary metabolites could identify metabolites determining the neonatal physiological status and discriminating between different metabolic states.
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[1]  
Barker DJ(2002)Fetal origins of adult disease: strength of effects and biological basis Int J Epidemiol 31 1235-1239
[2]  
Eriksson JG(2002)Renal aspects of the term and preterm infant: a selective update Curr Opin Pediatr 14 175-182
[3]  
Forsen T(2005)Nephron number, hypertension, renal disease, and renal failure J Am Soc Nephrol 16 2557-2564
[4]  
Osmond C(3rd)Glomerular number and size in autopsy kidneys: the relationship to birth weight Kidney Int 63 2113-2122
[5]  
Drukker A(2005)Developmental origins of the metabolic syndrome: prediction, plasticity, and programming Physiol Rev 85 571-633
[6]  
Guignard JP(2005)Developmental origins of health and disease N Engl J Med 353 1848-1850
[7]  
Hoy WE(1995)Analysis of fetal and neonatal urine using proton nuclear magnetic resonance spectroscopy Arch Dis Child Fetal Neonatal Ed 73 F153-F157
[8]  
Hughson MD(2003)Visualizing metabolic changes in breast-cancer tissue using 1H-NMR spectroscopy and self-organizing maps NMR Biomed 16 1-11
[9]  
Bertram JF(2005)NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition NMR Biomed 18 143-162
[10]  
Douglas-Denton R(1990)A comparison of N-1-methylnicotinamide clearance with 5 other markers of renal function in models of acute and chronic renal failure Toxicol Lett 53 243-245