Metabolic and structural impairment of skeletal muscle in heart failure

被引:0
作者
Cynthia Zizola
P. Christian Schulze
机构
[1] Columbia University Medical Center,Division of Cardiology, Department of Medicine, Center for Advanced Cardiac Care
来源
Heart Failure Reviews | 2013年 / 18卷
关键词
Skeletal muscle; Metabolism; Heart failure;
D O I
暂无
中图分类号
学科分类号
摘要
Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure upon skeletal muscle and exercise performance will be discussed with a focus on molecular, structural, and functional derangements in skeletal muscle of patients with heart failure.
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收藏
页码:623 / 630
页数:7
相关论文
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  • [1] Lunde PK(2001)Skeletal muscle disorders in heart failure Acta Physiol Scand 171 277-294
  • [2] Sjaastad I(1996)Exercise limitation in chronic heart failure: central role of the periphery J Am Coll Cardiol 28 1092-1102
  • [3] Schiotz Thorud HM(1990)Effect of dobutamine on skeletal muscle metabolism in patients with congestive heart failure Am J Cardiol 65 1121-1126
  • [4] Sejersted OM(1983)Failure of dobutamine to increase exercise capacity despite hemodynamic improvement in severe chronic heart failure Am J Cardiol 51 177-182
  • [5] Clark AL(1984)Impaired skeletal muscle nutritive flow during exercise in patients with congestive heart failure: role of cardiac pump dysfunction as determined by the effect of dobutamine Am J Cardiol 53 1308-1315
  • [6] Poole-Wilson PA(1970)Arterial sodium content in experimental congestive heart failure Circulation 41 213-216
  • [7] Coats AJ(1968)A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure J Clin Invest 47 960-970
  • [8] Mancini DM(1992)Active skeletal muscle mass and cardiopulmonary reserve. Failure to attain peak aerobic capacity during maximal bicycle exercise in patients with severe congestive heart failure Circulation 86 1351-1356
  • [9] Schwartz M(2003)Exercise training and skeletal muscle inflammation in chronic heart failure: feeling better about fatigue J Am Coll Cardiol 42 869-872
  • [10] Ferraro N(2008)Regulation of muscle mass by growth hormone and IGF-I Br J Pharmacol 154 557-568