Fluorescence of an eosine probe in solutions of human serum albumin with organic and inorganic ligands

The fluorescence of an eosine molecular probe in solutions of human serum albumin (HSA) in the presence of an inorganic (CsCl) and organic (sodium dodecyl sulfate, SDS) ligand was studied. The interaction of HSA molecules with these ligands was analyzed. It was demonstrated that the presence of CsCl, a low-molecular-weight salt, in the solutions influences the efficiency of the complexation of eosine with HSA. Data on the dynamics of the conformation rearrangement of HSA during denaturation under the action of SDS were obtained.