Bortezomib therapy for nephrotic syndrome due to idiopathic membranous nephropathy

被引：0

作者：

Choli Hartono

Miriam Chung

Sheng F. Kuo

Surya V. Seshan

Thangamani Muthukumar

机构：

[1] The Rogosin Institute,Division of Nephrology and Hypertension

[2] Weill Cornell Medical College,Department of Pathology

[3] New York Hospital Queens,undefined

[4] Flushing,undefined

[5] Weill Cornell Medical College,undefined

来源：

Journal of Nephrology | 2014年 / 27卷

关键词：

Bortezomib; Membranous nephropathy; Nephrotic syndrome; Proteasome inhibitor;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Idiopathic membranous nephropathy is a common cause of nephrotic syndrome in adults. The nephrotic syndrome due to idiopathic membranous nephropathy is often resistant to glucocorticosteroids and requires an alkylating agent such as chlorambucil or cyclophosphamide to induce remission. Recent studies illustrate that antibodies against the autoantigen M-type phospholipase A2 receptor contribute to a vast majority but not all cases of idiopathic membranous nephropathy. Herein, we report a patient with nephrotic syndrome due to membranous nephropathy that was resistant to 6 months of therapy with ramipril and high-dose glucocorticosteroids but responded to a single cycle of bortezomib infusion.

引用

页码：103 / 106

页数：3

共 35 条

[1]

Ponticelli C(2013)Glomerular diseases: membranous nephropathy—a modern view Clin J Am Soc Nephrol 21 697-704

[2]

Glassock RJ(2010)Spontaneous remission of nephrotic syndrome in idiopathic membranous nephropathy J Am Soc Nephrol 51 901-907

[3]

Polanco N(1997)Validation of a predictive model of idiopathic membranous nephropathy: its clinical and research implications Kidney Int 2 139-172

[4]

Gutierrez E(2012)KDIGO clinical practice guidelines for glomerulonephritis Kidney Int 361 11-21

[5]

Covarsi A(2009)M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy N Engl J Med 7 1394-1400

[6]

Cattran DC(2012)Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy Clin J Am Soc Nephrol 320 8-13

[7]

Pei Y(1989)A randomized trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy N Engl J Med 381 744-751

[8]

Greenwood CM(2013)Immunosuppression for progressive membranous nephropathy: a UK randomized controlled trial Lancet 368 90-92

[9]

Beck LH(2013)ADAMTS13 antibody depletion by bortezomib in thrombotic thrombocytopenic purpura N Engl J Med 22 2705-2708

[10]

Bonegio RGB(2007)IgA nephropathy in a patient with IgG lambda light-chain plasmacytoma: a rare coincidence Nephrol Dial Transplant 23 1416-1425

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