Synthesis and Biological Activity of Steroidal Tigogenin Hydrazones and Pyrazolines

被引：0
|
作者：
N. Sh. Nadaraia
M. L. Kakhabrishvili
N. N. Barbakadze
V. D. Mshvildadze
B. Sylla
J. Legault
A. Pichette
机构：
[1] Tbilisi State Medical University,I. G. Kutateladze Institute of Pharmacochemistry
[2] Universite Quebec a Chicoutimi,LASEVE
来源：
Chemistry of Natural Compounds | 2018年 / 54卷
关键词：
5; -steroids; synthesis; hydrazones; pyrazolines; cytotoxic and antibacterial activity;
D O I：
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学科分类号：
摘要：
Steroidal hydrazones and pyrazolines were synthesized via condensation of a series of 5α-steroidal ketones with several hydrazines. Their cytotoxic activity against cancer cultures (A549 lung cancer, DLD-1 colorectal cancer, and WS1 normal skin fibroblasts) and antibacterial activity against E. coli and S. aureus strains were studied. The structures of the synthesized compounds were elucidated using PMR, 13C NMR, and mass spectra.
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页码：926 / 929
页数：3
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