Vagus nerve stimulation in pediatric patients with failed epilepsy surgery

被引：0
作者：
Jeng-Dau Tsai
Pi-Chuan Fan
Wang-Tso Lee
Pi-Lien Hung
Kun-Long Hung
Huei-Shyong Wang
Kuang-Lin Lin
机构：
[1] Chung Shan Medical University and Hospital,School of Medicine and Department of Pediatrics
[2] National Taiwan University Hospital,Department of Pediatrics
[3] Chang Gung Memorial Hospital Kaohsiung,Department of Pediatrics
[4] Fu Jen Catholic University Hospital,Department of Pediatrics
[5] Fu Jen Catholic University,Division of Pediatric Neurology
[6] Chang Gung Children’s Hospital,undefined
[7] Vagus Nerve Stimulation Study Group of Taiwan Child Neurology Society,undefined
来源：
Acta Neurologica Belgica | 2021年 / 121卷
关键词：
Refractory epilepsy; Epilepsy surgery; Vagus nerve stimulation; Seizures frequency reduction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Adequate control of pharmacoresistant epilepsy continues to be a challenge. Multiple studies have reported the benefits of epilepsy surgery and vagus nerve stimulation for children with pharmacoresistant epilepsy. Little is known about the role of vagus nerve stimulation for children with failed epilepsy surgeries. The aim of this study was to examine the effects of vagus nerve stimulation on seizure frequency reduction for children with failed epilepsy surgeries. We retrospectively reviewed 85 children with pharmacoresistant epilepsy who underwent vagus nerve stimulation. Six of these patients underwent epilepsy surgery before vagus nerve stimulation (group I) and 79 patients received only vagus nerve stimulation (group II). We recorded seizure frequency at 3, 12, 24 and 36 months after vagus nerve stimulator implantation. Both groups had reduced seizure frequencies at the 3-, 12-, 24- and 36-month follow-up (p = 0.044 for group I trends and 0.008 for group II trends). Vagus nerve stimulator implantations significantly improve seizure frequency for children with or without previous epilepsy surgery at 3, 12, 24 and 36 months. These findings suggest that vagus nerve stimulation should be considered an alternative therapy for pediatric patients with previous failed surgeries.
引用
收藏
页码：1305 / 1309
页数：4
相关论文
共 80 条
  • [1] Wiebe S(2004)Effectiveness and safety of epilepsy surgery: what is the evidence? CNS Spectr 9 126-132
  • [2] Vakharia VN(2018)Getting the best outcomes from epilepsy surgery Ann Neurol. 83 676-690
  • [3] Duncan JS(2001)Prognostic factors in the surgical treatment of medically intractable epilepsy associated with mesial temporal sclerosis Acta Neurol Scand 103 344-350
  • [4] Witt J-A(2013)Is reoperation an option for patients with temporal lobe epilepsy after failure of surgery? Seizure 22 502-506
  • [5] Elger CE(2011)The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study Lancet 378 1388-1395
  • [6] Staba R(2012)Short-term results of vagus nerve stimulation in pediatric patients with refractory epilepsy Pediatr Neonatol 53 184-187
  • [7] Engel J(2012)Vagus nerve stimulation therapy in pediatric epilepsy: current understanding and future directions Pediatr Neonatol 53 155-156
  • [8] Hennessy MJ(2002)Vagus-nerve stimulation for the treatment of epilepsy Lancet Neurol 1 477-482
  • [9] Elwes RD(1992)Electrophysiological studies of cervical vagus nerve stimulation in humans: I EEG Effects Epilepsia 33 1013-1020
  • [10] Rabe-Hesketh S(2016)The neuropsychological outcome of pediatric patients with refractory epilepsy treated with VNS–A 24-month follow-up in Taiwan Epilepsy Behav. 56 95-98
12345678