Challenges in measuring measles case fatality ratios in settings without vital registration

被引：11
作者：
Cairns K.L. [1 ]
Nandy R. [2 ]
Grais R.F. [3 ]
机构：
[1] Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA 30333
[2] Health Section, UNICEF, New York, NY 10017
[3] Epicentre, Paris
来源：
Emerging Themes in Epidemiology | / 7卷 / 1期
关键词：
Measle; Rubella; Recall Period; Verbal Autopsy; Laboratory Confirmation;
D O I：
10.1186/1742-7622-7-4
中图分类号：
学科分类号：
摘要：
Measles, a highly infectious vaccine-preventable viral disease, is potentially fatal. Historically, measles case-fatality ratios (CFRs) have been reported to vary from 0.1% in the developed world to as high as 30% in emergency settings. Estimates of the global burden of mortality from measles, critical to prioritizing measles vaccination among other health interventions, are highly sensitive to the CFR estimates used in modeling; however, due to the lack of reliable, up-to-date data, considerable debate exists as to what CFR estimates are appropriate to use. To determine current measles CFRs in high-burden settings without vital registration we have conducted six retrospective measles mortality studies in such settings. This paper examines the methodological challenges of this work and our solutions to these challenges, including the integration of lessons from retrospective all-cause mortality studies into CFR studies, approaches to laboratory confirmation of outbreaks, and means of obtaining a representative sample of case-patients. Our experiences are relevant to those conducting retrospective CFR studies for measles or other diseases, and to those interested in all-cause mortality studies. © 2010 Cairns et al; licensee BioMed Central Ltd.
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  • [1] Perry R.T., Halsey N.A., The clinical significance of measles, J Infect Dis, 189, SUPPL. 1, pp. 194-16, (2004)
  • [2] Cliff A., Haggett P., Smallman-Raynor, Measles. An Historical Geography, pp. 272-301, (1993)
  • [3] Babbot F.L., Gordon J.E., Modern measles, Am J Med Sci, 228, pp. 334-61, (1954)
  • [4] Black F.L., Measles, Viral Infections of Humans: Epidemiology and Control, pp. 451-65, (1989)
  • [5] Generic Protocol for Determining Measles Case Fatality Rates in A Community, Either during An Epidemic or in A Highly Endemic Area
  • [6] Shears P., Berry A.M., Murphy R., Et al., Epidemiological assessment of the health and nutrition of Ethiopian refugees in emergency camps in Sudan, BMJ, 295, pp. 314-18, (1985)
  • [7] Porter J.D.H., Gastellu-Etchegorry M., Navarre I., Et al., Measles outbreaks in the Mozambican refugee camps in Malawi: The continued need for an effective vaccine, Int J Epidemiol, 19, 4, pp. 1072-77, (1990)
  • [8] Stein C.E., Birmingham M., Kurian M., Duclos P., Strebel P., The global burden of measles in the year 2000 - A model that uses country-specific indicators, Journal of Infectious Diseases, 187, SUPPL. 1, (2003)
  • [9] Wolfson L.J., Strebel P.M., Gacic-Dobo M., Hoekstra E.J., McFarland J.W., Hersh B.S., Measles I., Has the 2005 measles mortality reduction goal been achieved? A natural history modeling study, Lancet, 369, 9557, pp. 191-200, (2007)
  • [10] Wolfson L.J., Grais R.F., Luquero F.J., Birmingham M.E., Strebel P.F., Estimates of Measles Case Fatality Ratios: A Comprehensive Review of Community-Based Studies, Int J Epidemiol, 38, 1, pp. 192-205, (2009)
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