Preclinical Safety Assessment of the 5-HT2A Receptor Agonist PET Radioligand [11C]Cimbi-36

被引:0
作者
Anders Ettrup
Søren Holm
Martin Hansen
Muhammad Wasim
Martin Andreas Santini
Mikael Palner
Jacob Madsen
Claus Svarer
Jesper Langgaard Kristensen
Gitte Moos Knudsen
机构
[1] Copenhagen University Hospital,Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging (Cimbi)
[2] Rigshospitalet,PET and Cyclotron Unit
[3] Copenhagen University Hospital,Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences
[4] Rigshospitalet,undefined
[5] University of Copenhagen,undefined
来源
Molecular Imaging and Biology | 2013年 / 15卷
关键词
PET; Serotonin receptors; Hallucinogenic; Radiation dosimetry; Head-twitch response; Porcine;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:376 / 383
页数:7
相关论文
共 47 条
[1]  
Gonzalez-Maeso J(2007)Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior Neuron 53 439-452
[2]  
Weisstaub NV(2001)Multiple conformations of native and recombinant human 5-hydroxytryptamine(2a) receptors are labeled by agonists and discriminated by antagonists Mol Pharmacol 60 690-699
[3]  
Zhou M(2010)Measuring endogenous 5-HT release by emission tomography: promises and pitfalls J Cereb Blood Flow Metab 30 1682-1706
[4]  
Lopez-Gimenez JF(2005)Measurement of the proportion of D2 receptors configured in state of high affinity for agonists in vivo: a positron emission tomography study using [ J Pharmacol Exp Ther 315 80-90
[5]  
Villazon M(2010)C]N-propyl-norapomorphine and [ J Pharmacol Exp Ther 333 533-539
[6]  
Brea J(2010)C]raclopride in baboons Curr Top Behav Neurosci 3 219-245
[7]  
Paterson LM(2012)A comparative evaluation of the dopamine D(2/3) agonist radiotracer [ J Cereb Blood Flow Metab 32 685-695
[8]  
Tyacke RJ(2012)C](−)-N-propyl-norapomorphine and antagonist [ Synapse 66 880-884
[9]  
Nutt DJ(2011)C]raclopride to measure amphetamine-induced dopamine release in the human striatum Synapse 65 1119-1127
[10]  
Narendran R(2010)Imaging neurotransmitter release by drugs of abuse J Nucl Med 51 1763-1770