The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy

被引：0
作者：
Kathleen M. Hagen
Shalina S. Ousman
机构：
[1] University of Calgary,Department of Neuroscience, Hotchkiss Brain Institute
[2] University of Calgary,Departments of Clinical Neurosciences and Cell Biology and Anatomy, Hotchkiss Brain Institute
来源：
Journal of Neuroinflammation | / 18卷
关键词：
Peripheral nervous system; Chronic inflammatory demyelinating polyradiculoneuropathy; Immune system; Aging; Immunosenescence;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) consists of various autoimmune subtypes in which the peripheral nervous system (PNS) is attacked. CIDP can follow a relapsing-remitting or progressive course where the resultant demyelination caused by immune cells (e.g., T cells, macrophages) and antibodies can lead to disability in patients. Importantly, the age of CIDP patients has a role in their symptomology and specific variants have been associated with differing ages of onset. Furthermore, older patients have a decreased frequency of functional recovery after CIDP insult. This may be related to perturbations in immune cell populations that could exacerbate the disease with increasing age. In the present review, the immune profile of typical CIDP will be discussed followed by inferences into the potential role of relevant aging immune cell populations. Atypical variants will also be briefly reviewed followed by an examination of the available studies on the immunology underlying them.
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