A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors

[1] Tam SJ(2010)Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier Annu Rev Neurosci 33 379-408

[2] Watts RJ(1997)Neuropilin is a receptor for the axonal chemorepellent semaphorin III Cell 90 739-751

[3] He Z(1998)Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor Cell 92 735-745

[4] Tessier-Lavigne M(1999)A requirement for neuropilin-1 in embryonic vessel formation Development 126 4895-4902

[5] Soker S(2002)Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain J Biol Chem 277 24818-24825

[6] Takashima S(2006)Neuropilins in neoplasms: expression, regulation, and function Exp Cell Res 312 584-593

[7] Quan H(2011)A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumors Nature 478 399-403

[8] Kawasaki T(2011)Neuropilins: a new target for cancer therapy Cancers 3 1899-1928

[9] Kitsukawa T(2007)Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library J Mol Biol 366 815-829

[10] Bekku Y(2012)Anti-neuropilin-1 (MRNP1685A): unexpected pharmacokinetic differences across species, from preclinical models to humans Pharm Res 29 2512-2521

[1] Tam SJ(2010)Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier Annu Rev Neurosci 33 379-408

[2] Watts RJ(1997)Neuropilin is a receptor for the axonal chemorepellent semaphorin III Cell 90 739-751

[3] He Z(1998)Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor Cell 92 735-745

[4] Tessier-Lavigne M(1999)A requirement for neuropilin-1 in embryonic vessel formation Development 126 4895-4902

[5] Soker S(2002)Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain J Biol Chem 277 24818-24825

[6] Takashima S(2006)Neuropilins in neoplasms: expression, regulation, and function Exp Cell Res 312 584-593

[7] Quan H(2011)A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumors Nature 478 399-403

[8] Kawasaki T(2011)Neuropilins: a new target for cancer therapy Cancers 3 1899-1928

[9] Kitsukawa T(2007)Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library J Mol Biol 366 815-829

[10] Bekku Y(2012)Anti-neuropilin-1 (MRNP1685A): unexpected pharmacokinetic differences across species, from preclinical models to humans Pharm Res 29 2512-2521