Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

被引：0
作者：
L Nolan
P W M Johnson
A Ganesan
G Packham
S J Crabb
机构：
[1] Cancer Research UK Clinical Centre,
[2] School of Medicine,undefined
[3] University of Southampton,undefined
[4] Southampton General Hospital,undefined
[5] School of Chemistry,undefined
[6] University of Southampton,undefined
[7] Southampton General Hospital,undefined
来源：
British Journal of Cancer | 2008年 / 99卷
关键词：
histone deacetylase; inhibitor; combination therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Histone deacetylase inhibitors have progressed rapidly from the laboratory to clinical testing. This review highlights the promising data for their combination with a wide range of established and novel anticancer agents and discusses the mechanisms that underpin these interactions.
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页码：689 / 694
页数：5
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