Antileukemic and long-term effects of two regimens with or without TBI in allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia

被引：0

作者：

Q Y Dai

G Souillet

Y Bertrand

C Galambrun

N Bleyzac

A M Manel

B Bruno

A L Souillet

E Homole

M P Pages

P Berlier

M David

J C Berthier

B Massenavette

B Contamin

N Philippe

机构：

[1] Shanghai Second Medical University,Departments of Pediatrics

[2] Ruijin Hospital,Department of Pharmacy

[3] Immuno-hematology and Bone Marrow Transplantation,Department of Endocrinology

[4] Debrousse Hospital,undefined

[5] Debrousse Hospital,undefined

[6] Debrousse Hospital,undefined

[7] Paediatric intensive care unit,undefined

[8] Debrousse Hospital,undefined

来源：

Bone Marrow Transplantation | 2004年 / 34卷

关键词：

ALL; allogeneic BMT; BMT conditioning; late effect; children;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Between September 1986 and June 1997, 24 children with high-risk ALL in CR1 were allografted after TAM (fractionated TBI, high-dose Ara-C, and melphalan; n=10) or BAM protocol (busulfan, high-dose Ara-C, and melphalan; n=14). The EFS for transplants from sibling donors was 33% with TAM and 62% with BAM (P=0.148). The probability of acute GvHD was 70% with TAM and 15% with BAM (P=0.003). Four of 17 evaluable patients relapsed: one after TAM and three after BAM. In all, 46 other children transplanted in CR beyond CR1 were studied for sequelae. Long-term side effects were more frequent in TAM vs BAM. In children with ALL, busulfan may be a good alternative to TBI to improve the quality of life.

引用

页码：667 / 673

页数：6

共 89 条

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