Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

被引：0
|
作者：
S Saeed
C Logie
H G Stunnenberg
J H A Martens
机构：
[1] Faculty of Science,Department of Molecular Biology
[2] Nijmegen Centre for Molecular Life Sciences,undefined
[3] Radboud University,undefined
来源：
British Journal of Cancer | 2011年 / 104卷
关键词：
PML-RAR; RXR; PU.1 (SPI1); epigenome;
D O I：
暂无
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学科分类号：
摘要：
PML—RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML–RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.
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页码：554 / 558
页数：4
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