Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway

被引:0
作者
Jing Li
Lin Shen
Fu-rong Lu
You Qin
Rui Chen
Jia Li
Yan Li
Han-zi Zhan
Yuan-qiao He
机构
[1] Union Hospital,Department of Traditional Chinese Medicine
[2] Tongji Medical College,Department of Acupuncture & Moxibustion
[3] Huazhong University of Science and Technology,Department of Laboratory Animal Science
[4] Cancer Center,undefined
[5] Union Hospital,undefined
[6] Tongji Medical College,undefined
[7] Huazhong University of Science and Technology,undefined
[8] Hubei University of Chinese Medicine,undefined
[9] Nanchang University,undefined
[10] University of Pittsburgh School of Medicine,undefined
来源
Acta Pharmacologica Sinica | 2012年 / 33卷
关键词
plumbagin; anticancer drug; TNF-α; cisplatin; gastric carcinoma; apoptosis; NF-κB;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:242 / 249
页数:7
相关论文
共 165 条
[1]  
Qiao L(2009)Targeting apoptosis as an approach for gastrointestinal cancer therapy Drug Resist Update 12 55-64
[2]  
Wong BC(2005)Global cancer statistics, 2002 CA Cancer J Clin 55 74-108
[3]  
Parkin DM(2003)Cancer chemoprevention with dietary phytochemicals Nat Rev Cancer 3 768-80
[4]  
Bray F(2008)Clinical observation on trigonella foenum-graecum L total saponins in combinaiton with sulphanylureas in the treatment of type 2 diabetes mellitus Chin J Integr Med 14 56-60
[5]  
Ferlay J(2008)Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone — refractory prostate cancer Cancer Res 68 9024-32
[6]  
Pisani P(2004)Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their Phytother Res 18 934-37
[7]  
Surh YJ(2005) synergistic activity with isonicotinic acid hydrazide J Pharm Pharmacol 57 111-6
[8]  
Lu FR(2006)Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone Mol Cancer Ther 5 3209-21
[9]  
Shen L(2008)Plumbagin induces G Cancer Lett 259 82-98
[10]  
Qin Y(2010)-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells Mol Cell Biochem 335 181-93