Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder

被引：0
作者：
Ângelo B. Cunha
Ana C. Andreazza
Fabiano A. Gomes
Benicio N. Frey
Leonardo E. da Silveira
Carlos A. Gonçalves
Flávio Kapczinski
机构：
[1] Universidade Federal de Santa Maria,Department of Neuropsychiatry, Centro de Ciências da Saúde
[2] Universidade Federal do Rio Grande do Sul,Department of Biochemistry, Instituto de Ciências Básicas da Saúde
[3] Hospital de Clínicas de Porto Alegre,Bipolar Disorders Program, Centro de Pesquisas
[4] McGill University,McConnell Brain Imaging Centre, Montreal Neurological Institute
来源：
European Archives of Psychiatry and Clinical Neuroscience | 2008年 / 258卷
关键词：
bipolar disorder; high-sensitivity C-reactive protein; inflammation; Mania; pathophysiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
There has been an increasing interest in the role of the immune and inflammatory systems in mood disorders. Mood episodes are associated with changes in acute phase proteins such as high-sensitivity C-reactive protein (hsCRP). The present study investigated serum hsCRP in manic, depressed, and euthymic BD patients as compared to matched healthy controls. Serum hsCRP was assessed using an ultrasensitive assay of particle-enhanced immunoturbidimetric latex agglutination. Serum hsCRP levels were increased in manic BD patients, as compared to euthymic, depressed patients and healthy controls (P < 0.001). These findings add to the notion that changes in the inflammatory system take place during acute episodes of mania.
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页码：300 / 304
页数：4
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[1]  
Andreazza AC(2007)Serum S100B and antioxidant enzymes in bipolar patients J Psychiatry Res 41 523-529
[2]  
Cassini C(1997)Effect of partially modified retro-inverso analogues derived from C-reactive protein on the induction of nitric oxide synthesis in peritoneal macrophages Br J Pharmacol 120 1383-1389
[3]  
Rosa AR(2007)Similar frequency of abnormal correlation between serum leptin levels and BMI before and after olanzapine treatment in schizophrenia Int Clin Psychopharmacol 22 205-211
[4]  
Leite MC(2004)Bipolar disorder N Engl J Med 351 476-486
[5]  
de Almeida LM(1999)Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways J Immunol 163 3963-3968
[6]  
Nardin P(2006)Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes Neurosci Lett 398 215-219
[7]  
Cunha AB(2007)C-reactive protein: a nontraditional serum marker of cardiovascular risk Cardiovasc Pathol 16 14-21
[8]  
Cereser KM(2007)Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder Prog Neuropsychopharmacol Biol Psychiatry 31 952-955
[9]  
Santin A(2007)Association among C-reactive protein, oxidative stress, and traditional risk factors in healthy Japanese subjects Int J Cardiol 115 63-66
[10]  
Gottfried C(1998)Development of a new microparticle-enhanced turbidimetric assay for C-reactive protein with superior features in analytical sensitivity and dynamic range J Clin Lab Anal 12 137-144
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