Circulating tumor DNA in hepatocellular carcinoma: trends and challenges

被引：0

作者：

Jia-Cheng Tang

Yi-Li Feng

Tao Guo

An-Yong Xie

Xiu-Jun Cai

机构：

[1] Zhejiang University,Zhejiang Province Key Laboratory of Laparoscopic Technology, Sir Run Run Shaw Hospital

[2] Zhejiang University,Institute of Translational Medicine

来源：

Cell & Bioscience | / 6卷

关键词：

Cell free DNA; Circulating tumor DNA; Biomarker; Liquid biopsy; Hepatocellular carcinoma;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Molecular characterization of individual patients’ tumor cells is becoming increasingly important in offering effective treatment for patients in clinical practice. Recent advances in the field have indicated that circulating tumor DNA (ctDNA) has huge potential to serve as a biomarker for early detection and precision treatment as well as prognosis of hepatocellular carcinoma (HCC). As ctDNA in HCC patients harbors the molecular characteristics of HCC tumor cells, ctDNA analysis in the blood may be sufficient for convenient, non-invasive and accurate detection, providing information for HCC diagnosis, treatment and prognosis. In this review, we will summarize and discuss current trends and challenges of ctDNA application in HCC.

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