Update on Treatment Advances in Combined-Modality Therapy for Anal and Rectal Carcinomas

被引:0
作者
Jeffrey Meyer
Glen Balch
Christopher Willett
Brian Czito
机构
[1] UT-Southwestern Medical Center,Department of Radiation Oncology
[2] UT-Southwestern Medical Center,Department of Surgery, Division of Surgical Oncology
[3] Duke University Medical Center,Department of Radiation Oncology
来源
Current Oncology Reports | 2011年 / 13卷
关键词
Anal cancer; Rectal cancer; Chemotherapy; Radiation; Combined modality;
D O I
暂无
中图分类号
学科分类号
摘要
Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy regimens in an effort to maximize tumor responses while reducing normal tissue toxicity. This review will discuss established regimens as well as newer and novel treatment approaches to treatment of anal and rectal cancer.
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页码:177 / 185
页数:8
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[21]  
Miwa M(1991)Preoperative versus postoperative chemoradiotherapy for rectal cancer New Engl J Med 324 709-1123
[22]  
Ura M(2004)Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203 New Engl J Med 351 1731-460
[23]  
Nishida M(2006)Chemotherapy with preoperative radiotherapy in rectal cancer J Clin Oncol 24 4620-701
[24]  
Glynne-Jones R(2006)Mesorectal excision for rectal cancer New Engl J Med 355 1114-434
[25]  
Meadows H(1993)The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma Lancet 341 457-1644
[26]  
Wan S(2007)Capecitabine (Cape) versus 5-fluorouracil (5-FU)-based neo-adjuvant chemotherapy for locally advanced rectal cancer (LARC): safety results of a randomized, phase III trial (abstr. 4013) Ann Surg 246 693-286
[27]  
Sawada N(2009)Inhibitory effects of oxaliplatin in experimental radiation treatment of colorectal carcinoma: does oxaliplatin improve 5-fluorouracil-dependent radiosensitivity? J Clin Oncol 27 171s-3026
[28]  
Kondoh K(2008)Preoperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: Pathologic response analysis of the Studio Terapia Adiuvante Reto (STAR)-01 randomized phase III trial (Abst#4008) Radiother Oncol 86 428-62
[29]  
Mori K(2009)Comparison of two neodadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2 J Clin Oncol 27 804s-830
[30]  
Eng C(2010)Cetuximab and chemoradiation for rectal cancer—is the water getting muddy? J Clin Oncol 28 1638-S28