Update on Treatment Advances in Combined-Modality Therapy for Anal and Rectal Carcinomas

被引:0
作者
Jeffrey Meyer
Glen Balch
Christopher Willett
Brian Czito
机构
[1] UT-Southwestern Medical Center,Department of Radiation Oncology
[2] UT-Southwestern Medical Center,Department of Surgery, Division of Surgical Oncology
[3] Duke University Medical Center,Department of Radiation Oncology
来源
Current Oncology Reports | 2011年 / 13卷
关键词
Anal cancer; Rectal cancer; Chemotherapy; Radiation; Combined modality;
D O I
暂无
中图分类号
学科分类号
摘要
Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy regimens in an effort to maximize tumor responses while reducing normal tissue toxicity. This review will discuss established regimens as well as newer and novel treatment approaches to treatment of anal and rectal cancer.
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收藏
页码:177 / 185
页数:8
相关论文
共 148 条
[1]  
Nigro ND(1977)Combined therapy for cancer of the anal canal: a follow-up report Dis Colon Rectum 20 677-678
[2]  
Vaitkevicius VK(2010)Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomized UKCCCR Anal Cancer Trial (ACT I) Br J Cancer 102 1123-1128
[3]  
Considine B(1997)Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the european organization for research and treatment of cancer radiotherapy and gastrointestinal cooperative groups J Clin Oncol 15 2040-2049
[4]  
Northover J(1996)Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study J Clin Oncol 14 2527-2539
[5]  
Glynne-Jones R(2008)Fluorouraicl, mitomhycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal. A randomized controlled trial JAMA 299 1914-1921
[6]  
Sebag-Montefiore D(2007)Neoadjuvant cisplatin chemotherapy before chemoradiation: a flawed paradigm? J Clin Oncol 20 5281-5286
[7]  
Bartelink H(2009)A randomized trial of chemoradiation using mitomycin or cisplatin, with or without maintenance cisplatin/5FU in squamous cell carcinoma of the anus (ACT II) [suppl; abstr LBA4009] J Clin Oncol 27 18s-1281
[8]  
Roelofsen F(1998)Design of a novel oral fluorpyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumors by enzymes concentrated in human liver and cancer tissue Eur J Cancer 34 1274-126
[9]  
Eschwege F(2008)EXTRA- a multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancer Int J Radiat Oncol Biol Phys 72 119-778
[10]  
Flam M(2007)Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric xenografts Oncol Rep 18 775-6560