Short-Term Chloral Hydrate Administration and Cancer in Humans

被引：0
作者：
Tmirah Haselkorn
Alice S. Whittemore
Natalia Udaltsova
Gary D. Friedman
机构：
[1] Stanford University School of Medicine,Division of Epidemiology, Department of Health Research & Policy
[2] Kaiser Permanente Medical Care Program,Division of Research
来源：
Drug Safety | 2006年 / 29卷
关键词：
Chloral Hydrate; Benign Prostatic Hypertrophy; Exposed Subject; Skin Melanoma; Hepatocellular Adenoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: Chloral hydrate, used as a hypnosedative in adults and children, has been shown to be genotoxic and carcinogenic in animal studies. We investigated the potential causal association between chloral hydrate exposure and cancer risk in humans.
引用
收藏
页码：67 / 77
页数：10
相关论文
共 64 条
[1]  
Graham SR(1988)Overdose with chloral hydrate: a pharmacological and therapeutic review Med J Aust 149 686-8
[2]  
Day RO(1990)Chloral hydrate warning [letter] Science 250 359-6
[3]  
Lee R(1993)Should chloral hydrate be banned? Pediatrics 92 442-8
[4]  
Smith MT(1998)Studies on the mutagenic and carcinogenic potential of chloral hydrate Arzneimittel Forschung 48 961-9
[5]  
Steinberg AD(1996)Suicidal chloral hydrate poisoning J Toxicol Clin Toxicol 34 97-76
[6]  
Leuschner J(1998)Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/− (−) 3.7.2C mouse lymphoma cells Mutat Res 413 265-21
[7]  
Beuscher N(1995)Potential carcinogenicity of chloral hydrate: a review J Toxicol Clin Toxicol 33 115-37
[8]  
Ludwigs U(1986)Review of literature on chemical-induced aneuploidy in mammalian male germ cells Mutat Res 167 123-86
[9]  
Divino Filho J(1995)Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes Mutagenesis 10 477-53
[10]  
Magnusson A(1993)Have animal data been used inappropriately to estimate risks to humans from environmental trichloroethylene? Regul Toxicol Pharmacol 18 137-203
1234567