Detecting, quantifying and adjusting for publication bias in meta-analyses: protocol of a systematic review on methods.

被引:29
作者
Mueller K.F. [1 ]
Meerpohl J.J. [1 ]
Briel M. [1 ]
Antes G. [1 ]
von Elm E. [1 ]
Lang B. [1 ]
Gloy V. [1 ]
Motschall E. [1 ]
Schwarzer G. [1 ]
Bassler D. [1 ]
机构
[1] Center for Pediatric Clinical Studies, University Children's Hospital Tuebingen, Tuebingen, Frondsbergstraße 23
关键词
Publication bias; Full publication; Underreporting; Detecting; Quantifying; The OPEN project;
D O I
10.1186/2046-4053-2-60
中图分类号
学科分类号
摘要
Health professionals and policymakers aspire to make healthcare decisions based on the entire relevant research evidence. This, however, can rarely be achieved because a considerable amount of research findings are not published, especially in case of 'negative' results - a phenomenon widely recognized as publication bias. Different methods of detecting, quantifying and adjusting for publication bias in meta-analyses have been described in the literature, such as graphical approaches and formal statistical tests to detect publication bias, and statistical approaches to modify effect sizes to adjust a pooled estimate when the presence of publication bias is suspected. An up-to-date systematic review of the existing methods is lacking. The objectives of this systematic review are as follows:• To systematically review methodological articles which focus on non-publication of studies and to describe methods of detecting and/or quantifying and/or adjusting for publication bias in meta-analyses.• To appraise strengths and weaknesses of methods, the resources they require, and the conditions under which the method could be used, based on findings of included studies.We will systematically search Web of Science, Medline, and the Cochrane Library for methodological articles that describe at least one method of detecting and/or quantifying and/or adjusting for publication bias in meta-analyses. A dedicated data extraction form is developed and pilot-tested. Working in teams of two, we will independently extract relevant information from each eligible article. As this will be a qualitative systematic review, data reporting will involve a descriptive summary. Results are expected to be publicly available in mid 2013. This systematic review together with the results of other systematic reviews of the OPEN project (To Overcome Failure to Publish Negative Findings) will serve as a basis for the development of future policies and guidelines regarding the assessment and handling of publication bias in meta-analyses.
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共 83 条
[1]  
Easterbrook PJ(1991)Publication bias in clinical research Lancet 337 867-872
[2]  
Berlin JA(1990)The existence of publication bias and risk factors for its occurrence JAMA 263 1385-1389
[3]  
Gopalan R(2008)Systematic review of the empirical evidence of study publication bias and outcome reporting bias PLoS One 3 e3081-115
[4]  
Matthews DR(2000)Publication and related biases Health Technol Assess 4 1-1541
[5]  
Dickersin K(1986)Publication bias: the case for an international registry of clinical trials J Clin Oncol 4 1529-638
[6]  
Dwan K(2004)Compulsory registration of clinical trials BMJ 329 637-2787
[7]  
Altman DG(2005)Trial Registration at ClinicalTrials.gov between May and October 2005 N Engl J Med 353 2779-634
[8]  
Arnaiz JA(1997)Bias in meta-analysis detected by a simple, graphical test BMJ 315 629-463
[9]  
Bloom J(2000)Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis Biometrics 56 455-296
[10]  
Chan AW(1994)Invited commentary: a critical look at some popular meta-analytic methods Am J Epidemiol 140 290-901