Drug development for intraperitoneal chemotherapy against peritoneal carcinomatosis from gastrointestinal cancer

被引：0
|
作者：
Shigenobu Emoto
Eiji Sunami
Hironori Yamaguchi
Soichiro Ishihara
Joji Kitayama
Toshiaki Watanabe
机构：
[1] The University of Tokyo,Department of Surgical Oncology
来源：
Surgery Today | 2014年 / 44卷
关键词：
Colorectal cancer; Gastric cancer; Intraperitoneal chemotherapy; Peritoneal carcinomatosis; Pharmacokinetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intraperitoneal (IP) chemotherapy for peritoneal carcinomatosis (PC) from gastrointestinal cancer has been investigated and applied clinically for several decades. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy have been considered to be the optimal treatment options for selected patients with colorectal and gastric cancers with PC. Accumulating evidence suggests that the administration of IP paclitaxel for patients with PC from gastric cancer may improve the patient survival. The pharmacokinetics of such treatment should be considered to optimize IP chemotherapy. In addition, newly emerging molecular-targeted therapies and research into new drug delivery systems, such as nanomedicine or controlled absorption/release methods, are essential to improve the effects of IP chemotherapy. This review summarizes the current status and future prospects of IP chemotherapy for the treatment of gastrointestinal cancer.
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页码：2209 / 2220
页数：11
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