Evaluation of cardiac allograft vasculopathy by positron emission tomography

被引：0
作者：
Attila Feher
Albert J. Sinusas
机构：
[1] Yale University School of Medicine,Section of Cardiovascular Medicine, Department of Internal Medicine
[2] Yale School of Medicine,Department of Radiology and Biomedical Imaging
[3] Yale University,Department of Biomedical Engineering
来源：
Journal of Nuclear Cardiology | 2021年 / 28卷
关键词：
Myocardial flow reserve; coronary flow reserve; positron emission tomography; allograft vasculopathy; heart transplantation; myocardial blood flow; nuclear cardiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cardiac allograft vasculopathy (CAV) remains one of the most important late occurring complications in heart transplant (HT) recipients significantly effecting graft survival. Recently, there has been tremendous focus on the development of effective and safe non-invasive diagnostic strategies for the diagnosis of CAV employing a wide range of imaging technologies. During the past decade multiple studies have been published using positron emission tomography (PET) myocardial perfusion imaging, establishing the value of PET myocardial blood flow quantification for the evaluation of CAV. These independent investigations demonstrate that PET can be successfully used to establish the diagnosis of CAV, can be utilized for prognostication and may be used for serial monitoring of HT recipients. In addition, molecular imaging techniques have started to emerge as new tools to enhance our knowledge to better understand the pathophysiology of CAV.
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页码：2616 / 2628
页数：12
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[1]  
Wang Y(2004)Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries FASEB J 18 606-608
[2]  
Burns WR(1991)Induced expression of endothelial-leukocyte adhesion molecules in human cardiac allografts Transplantation 51 537-539
[3]  
Tang PC(2013)Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-kappaB signaling in endothelial cells Circulation 128 2504-2516
[4]  
Yi T(1995)Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection Transplantation 59 572-578
[5]  
Schechner JS(2008)HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway J Immunol 180 2357-2366
[6]  
Zerwes HG(2007)Prognostic impact of microvasculopathy on survival after heart transplantation: evidence from 9713 endomyocardial biopsies Circulation 116 1274-1282
[7]  
Briscoe DM(2016)The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update J Heart Lung Transplant 35 1-23
[8]  
Schoen FJ(1992)Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of “angiographically silent” intimal thickening Circulation 85 979-987
[9]  
Rice GE(2017)Coronary endothelial dysfunction and the index of microcirculatory resistance as a marker of subsequent development of cardiac allograft vasculopathy Circulation 135 1093-1095
[10]  
Bevilacqua MP(2016)Invasive assessment of coronary physiology predicts late mortality after heart transplantation Circulation 133 1945-1950
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