Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice

被引：70

作者：

Zhou Z. ^{[1
]}

Christofidou-Solomidou M. ^{[1
]}

Garlanda C. ^{[2
]}

DeLisser H.M. ^{[1
,3
]}

机构：

[1] Pulmonary and Critical Care Division, Department of Medicine, Univ. of Pennsylvania Medical Center, Philadelphia, PA

[2] Mario Negri Inst. Pharmacol. Res., Milan

[3] Philadelphia, PA 19104-6160, 806 BRB II/III

来源：

Angiogenesis | 1999年 / 3卷 / 2期

关键词：

Angiogenesis; Cell adhesion; PECAM-1;

D O I：

10.1023/A:1009092107382

中图分类号：

学科分类号：

摘要：

Platelet endothelial cell adhesion molecule (PECAM-1/CD31), a member of the immunoglobulin superfamily expressed at high levels on endothelial cells, has been recently implicated in angiogenesis. Although antagonism of PECAM-1 inhibited neovascularization in two different animal models of growth factor/chemokine-induced angiogenesis, its participation in tumor angiogenesis has not been established. We therefore investigated its involvement in models of tumor angiogenesis in mice. An antibody against murine PECAM-1 that was shown to block in vitro murine endothelial tube formation inhibited the subcutaneous growth and tumor vascularity of three tumors in mice: A549 human non-small cell lung cancer in SCID mice, B16 murine melanoma in C57BL/6 mice and AB12 murine mesothelioma in Balb/c mice. These studies suggest a possible role for PECAM-1 in the complex process of tumor angiogenesis and provide additional evidence of the importance of endothelial cell adhesion molecules to the formation of new vessels.

引用

页码：181 / 188

页数：7

共 25 条

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