Polyelectrolyte micro- and nanoparticles with doxorubicin

被引：3
|
作者：
Averin P.S. [1 ]
Lopes de Gerenyu A.V. [1 ]
Balabushevich N.G. [1 ]
机构：
[1] Department of Chemistry, Moscow State University, Moscow
来源：
Moscow University Chemistry Bulletin | 2016年 / 71卷 / 2期
关键词：
chitosan; dextran sulfate; doxorubicin; layer-by-layer biopolyelectrolyte adsorption; microencapsulation;
D O I：
10.3103/S0027131416020012
中图分类号：
学科分类号：
摘要：
Doxorubicin-containing micro- and nanoparticles obtained by layer-by-layer adsorption of dextran sulfate and chitosan on an insoluble antibiotic–polyanion complex with subsequent sonication were studied. The effects of the molecular mass of biopolymers, the number of polyelectrolyte layers, and the pH of the reaction medium on the composition, physicochemical properties, and the efficiency of doxorubicin incorporation have been examined. The release of doxorubicin and the mucoadhesive properties of the polyelectrolyte particles have been analyzed to determine the possibilities of their potential applications. © 2016, Allerton Press, Inc.
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页码：140 / 145
页数：5
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