Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy

被引：10

作者：

Frustaci A. ^{[1
]}

Petrosillo N. ^{[1
]}

Francone M. ^{[2
]}

Verardo R. ^{[1
]}

Ippolito G. ^{[1
]}

Chimenti C. ^{[1
]}

机构：

[1] National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Biocardiology Laboratory, Rome

[2] La Sapienza University, Radiological Sciences Department, Rome

来源：

BMC Infectious Diseases | / 14卷 / 1期

关键词：

Biopsy (Heart); Heart failure; HIV (Human immunodeficiency virus); Myocarditis; Recovery of function;

D O I：

10.1186/s12879-014-0729-3

中图分类号：

学科分类号：

摘要：

Background: Dilated cardiomyopathy occurring in HIV-infected patients raises both diagnostic and therapeutic challenging problems. Indeed myocardial involvement in HIV infection has been variously attributed to several causes, including viral, toxic, nutritional and autoimmune, but no specific treatment capable to substantially improve patients' prognosis has been recognized so far. Case Presentation: Hereby we describe the case of an autoimmune myocarditis manifesting with heart failure in a3 9-year-old man with HIV infection. Conclusion: Presence of auto-reactive myocarditis should be considered in patients with HIV-associated dilated cardiomyopathy. Its recognition by endomyocardial biopsy followed by steroid administration may result in a complete resolution of cardiac disease. © Frustaci et al.

引用

共 13 条

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[12] Currie P.F., Goldman J.H., Caforio A.L., Jacob A.J., Baig M.K., Brettle R.P., Boon N.A., McKenna W.J., Evidence of cardiac autoimmunity in HIV related heart muscle disease, Heart, 79, 6, pp. 599-604, (1998)
[13] Via C.S., Morse H.C., Shearer G.M., Altered immunoregulation and autoimmune aspects of HIV infection: relevant murine models, Immunol Today, 11, pp. 250-255, (1990)

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