Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomas

被引：0
作者：
S Andersson
K-L Wallin
A-C Hellström
L E Morrison
A Hjerpe
G Auer
T Ried
C Larsson
K Heselmeyer-Haddad
机构：
[1] Intervention and Technology,Department for Clinical Science, Division of Obstetrics and Gynecology
[2] Karolinska University Hospital-Huddinge,Department of Molecular Medicine and Surgery
[3] Karolinska Institutet,Department of Gynecologic Oncology
[4] Karolinska Institutet,Department of Oncology
[5] Karolinska University Hospital-Solna,Pathology
[6] CMM L8:0,undefined
[7] Radiumhemmet,undefined
[8] Karolinska University Hospital-Solna,undefined
[9] Abbott Molecular,undefined
[10] 1300 East Touhy Avenue,undefined
[11] Karolinska University Hospital Solna,undefined
[12] CCK,undefined
[13] Genetics Branch,undefined
[14] Center for Cancer Research,undefined
[15] National Cancer Institute/NIH,undefined
[16] Building 50,undefined
[17] Room 1408,undefined
[18] 50 South Drive,undefined
来源：
British Journal of Cancer | 2006年 / 95卷
关键词：
cervical adenocarcinoma; human papillomavirus; interphase fluorescence ; hybridisation; chromosome arm 3q; telomerase; early detection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The level of genomic amplification of the human telomerase gene TERC, which maps to chromosome band 3q26, was determined in primary cervical adenocarcinomas. Interphase nuclei prepared from archival material of 12 primary cervical adenocarcinomas, eight of which were human papillomavirus positive, were hybridised with a triple colour probe set specific for centromeres of chromosomes 3 and 7 and the TERC gene. We observed high proportions of nuclei with increased absolute copy numbers for TERC in all tumours (mean 3.3; range 2.3–5.2). Amplification of the human telomerase gene TERC is a consistent aberration in cervical adenocarcinomas. Therefore, application of our probe set may provide an objective genetic test for the assessment of glandular cells in Pap smears and hence for the diagnosis of cervical adenocarcinomas.
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页码：331 / 338
页数：7
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