Alpha-interferon for the treatment of idiopathic sudden sensorineural hearing loss

被引：0
作者：
S. Kanemaru
H. Fukushima
H. Nakamura
H. Tamaki
Y. Fukuyama
Y. Tamura
机构：
[1] Kitano Hospital,Department of Otolaryngology
来源：
European Archives of Oto-Rhino-Laryngology | 1997年 / 254卷
关键词：
Idiopathic sudden sensorineural hearing loss; Interferon-α treatment; Anti-viral activity; 2′-5′ oligoadenylate synthetase; Cytokine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We have employed alpha-interferon (IFN-α), an anti-viral agent, in the treatment of severe idiopathic sudden sensorineural hearing loss (ISSHL). Forty-two patients were studied and had an average hearing ability of ≥ 70 dB before treatment. We also examined 2′-5′ oligoadenylate synthetase (2,5A-S) activity, one of the parameters indicating anti-viral activity of IFN, to investigate the relationship between the suppression of viral proliferation and prognosis and explain the pathogenesis of ISSHL. Complete recovery was found in 27 patients (64.3%) after IFN therapy. Increased 2,5A-S activity was observed on the 3rd day of IFN therapy in 24 of the 27 patients who completely recovered. No severe adverse events were reported after IFN therapy. Findings suggest that IFN therapy may be effective and safe in the treatment of ISSHL and calls for further investigation.
引用
收藏
页码：158 / 162
页数：4
相关论文
共 60 条
[1]  
Brown G(1976)Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: dependence on double-stranded RNA Biochem Biophys Res Commun 69 114-122
[2]  
Lebleu B(1993)2′,5′-Oligoadenylate synthetase activity as a responsive marker during interferon therapy for chronic hepatitis-C J Interferon Res 13 57-60
[3]  
Kawakita M(1994)Sudden hearing loss associated with Interferon Lancet 343 1134-1135
[4]  
Shaila S(1991)The efficacy of lasixvitamin therapy (L-V therapy) for sudden deafness and other sensorineural hearing loss Acta Otolaryngol (Stockh) 486 78-91
[5]  
Sen G(1989)Idiopathic sudden sensorineural hearing loss Am J Otol 10 242-247
[6]  
Lengyel P(1992)Modulation of 2′,5′-oligoadenylate synthetase in patients treated with alpha-interferon — effects of dose, schedule, and route of administration J Interferon Res 14 7-16
[7]  
Giannelli G(1990)Idiopathic sudden sensorineural hearing loss and viral labyrinthitis Ann Otol Rhinol Laryngol 99 969-976
[8]  
Antonelli G(1985)Interferons and natural killer cells Br Med Bull 41 22-27
[9]  
Fera G(1986)The pathology of idiopathic sudden sensorineural hearing loss Arch Otorhinolaryngol 243 1-15
[10]  
Dianzani F(1962)The pathology of sudden deafness Laryngoscope 72 1142-1157
123456