Basaloid squamous cell carcinoma in the nasal cavity treated with proton beam therapy concurrent with cisplatin: A case report

被引:4
作者
Takamatsu S. [1 ]
Yamamoto K. [1 ]
Kondou T. [2 ]
Kawamura M. [1 ]
Asahi S. [1 ]
Tameshige Y. [1 ]
Maeda Y. [1 ]
Sasaki M. [1 ]
Tamamura H. [1 ]
Tsuji A. [3 ]
Kaizaki Y. [4 ]
Kumano T. [5 ]
Takanaka T. [5 ]
机构
[1] Proton Therapy Center, Fukui Prefectural Hospital, Fukui City, Fukui 910-8526
[2] Department of Diagnostic and Therapeutic Radiology, Kanazawa Medical University, Uchinada, Kahoku, Ishikawa 920-0923
[3] Division of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa city, Ishikawa 920-8640
[4] Department of Pathology, Fukui Prefectural Hospital, Fukui City, Fukui 910-8526
[5] Department of Radiotherapy, Graduate School of Medicine, Kanazawa University, Kanazawa city, Ishikawa 920-8640
关键词
Basaloid squamous cell carcinoma; Cisplatin; Concurrent radiochemotherapy; Nasal cavity; Proton beam therapy;
D O I
10.1186/1752-1947-8-123
中图分类号
学科分类号
摘要
Introduction. Basaloid squamous cell carcinoma is a rare and aggressive variant of squamous cell carcinoma. Basaloid squamous cell carcinoma is mostly seen in the upper aerodigestive tract and has a propensity for lymph node spread and systemic metastases. Various treatment modalities have been reported, including surgical excision supplemented with radiotherapy/adjuvant chemotherapy. To the best of our knowledge, treatment of nasal basaloid squamous cell carcinoma with proton beam therapy and cisplatin has not been described in the literature. Case presentation. We report the case of a 56-year-old Japanese man with locally invasive basaloid squamous cell carcinoma in his right nasal cavity with invasion of the orbit, paranasal sinus, and buccal subcutaneous tissue. He underwent proton beam therapy concurrent with cisplatin. Acute and late side effects did not exceed grade 3. At 24-month follow up, he remains in complete remission. Conclusion: Proton beam therapy concurrent with cisplatin may be one choice for locally invasive basaloid squamous cell carcinoma. © 2014 Takamatsu et al.; licensee BioMed Central Ltd.
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