Nocardithiocin, a novel thiopeptide antibiotic, produced by pathogenic Nocardia pseudobrasiliensis IFM 0757

被引：0

作者：

Akira Mukai

Toshio Fukai

Yasutaka Hoshino

Katsukiyo Yazawa

Ken-ichi Harada

Yuzuru Mikami

机构：

[1] Medical Mycology Research Center,Department of Bioactive Molecules

[2] Chiba University,undefined

[3] Chuo-ku,undefined

[4] Chiba,undefined

[5] Japan,undefined

[6] School of Pharmaceutical Sciences,undefined

[7] Toho University,undefined

[8] Funabashi,undefined

[9] Chiba,undefined

[10] Japan,undefined

[11] National Institute of Infectious Diseases,undefined

[12] Shinjuku-ku,undefined

[13] Tokyo,undefined

[14] Japan,undefined

[15] Graduate School of Environmental and Human Science & Faculty of Pharmacy,undefined

[16] Meijo University,undefined

[17] Tempaku,undefined

[18] Nagoya,undefined

[19] Japan,undefined

[20] 5Current address: Department of Health Pharmacy,undefined

[21] Yokohama College of Pharmacy,undefined

[22] 601 Matano-cho,undefined

[23] Totsuka-ku,undefined

[24] Yokohama,undefined

[25] Kanagawa 245-0066,undefined

[26] Japan,undefined

来源：

The Journal of Antibiotics | 2009年 / 62卷

关键词：

nocardithiocin; pathogenic actinomycetes; rifampicin-resistant mycobacteria; thiopeptide;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Nocardithiocin is a novel thiopeptide compound produced by the pathogenic Nocardia pseudobrasiliensis strain IFM 0757. It shows a strong activity against acid-fast bacilli such as the Mycobacterium and Gordonia species. Nocardithiocin was highly active against rifampicin-resistant as well as -sensitive Mycobacterium tuberculosis strains, and most of the resistant strains were inhibited at concentrations ranging from 0.025 to 1.56 μg ml−1. The structure of the thiopeptide antibiotic containing thiazole, natural and unnatural amino acids was elucidated by MS and NMR spectral analyses.

引用

页码：613 / 619

页数：6

共 45 条

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