Nocardithiocin, a novel thiopeptide antibiotic, produced by pathogenic Nocardia pseudobrasiliensis IFM 0757

被引：0
作者：
Akira Mukai
Toshio Fukai
Yasutaka Hoshino
Katsukiyo Yazawa
Ken-ichi Harada
Yuzuru Mikami
机构：
[1] Medical Mycology Research Center,Department of Bioactive Molecules
[2] Chiba University,undefined
[3] Chuo-ku,undefined
[4] Chiba,undefined
[5] Japan,undefined
[6] School of Pharmaceutical Sciences,undefined
[7] Toho University,undefined
[8] Funabashi,undefined
[9] Chiba,undefined
[10] Japan,undefined
[11] National Institute of Infectious Diseases,undefined
[12] Shinjuku-ku,undefined
[13] Tokyo,undefined
[14] Japan,undefined
[15] Graduate School of Environmental and Human Science & Faculty of Pharmacy,undefined
[16] Meijo University,undefined
[17] Tempaku,undefined
[18] Nagoya,undefined
[19] Japan,undefined
[20] 5Current address: Department of Health Pharmacy,undefined
[21] Yokohama College of Pharmacy,undefined
[22] 601 Matano-cho,undefined
[23] Totsuka-ku,undefined
[24] Yokohama,undefined
[25] Kanagawa 245-0066,undefined
[26] Japan,undefined
来源：
The Journal of Antibiotics | 2009年 / 62卷
关键词：
nocardithiocin; pathogenic actinomycetes; rifampicin-resistant mycobacteria; thiopeptide;
D O I：
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中图分类号：
学科分类号：
摘要：
Nocardithiocin is a novel thiopeptide compound produced by the pathogenic Nocardia pseudobrasiliensis strain IFM 0757. It shows a strong activity against acid-fast bacilli such as the Mycobacterium and Gordonia species. Nocardithiocin was highly active against rifampicin-resistant as well as -sensitive Mycobacterium tuberculosis strains, and most of the resistant strains were inhibited at concentrations ranging from 0.025 to 1.56 μg ml−1. The structure of the thiopeptide antibiotic containing thiazole, natural and unnatural amino acids was elucidated by MS and NMR spectral analyses.
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页码：613 / 619
页数：6
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