Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

被引:0
作者
C. Ling
S. Del Guerra
R. Lupi
T. Rönn
C. Granhall
H. Luthman
P. Masiello
P. Marchetti
L. Groop
S. Del Prato
机构
[1] Lund University,Department of Clinical Sciences, Diabetes and Endocrinology
[2] CRC,Department of Endocrinology and Metabolism, Metabolic Unit
[3] University of Pisa,undefined
来源
Diabetologia | 2008年 / 51卷
关键词
DNA methylation; Epigenetic; Gene expression; Genetic; Human; Pancreatic islets; PGC-1α; Type 2 diabetes;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:615 / 622
页数:7
相关论文
共 68 条
[1]  
Lin J(2005)Metabolic control through the PGC-1 family of transcription coactivators Cell Metab 1 361-370
[2]  
Handschin C(2003)PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes Nat Genet 34 267-273
[3]  
Spiegelman BM(2001)Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to type II diabetes mellitus Diabetologia 44 2220-2226
[4]  
Mootha VK(2006)Meta-analysis of the Gly482Ser variant in Diabetologia 49 501-505
[5]  
Lindgren CM(2004) in type 2 diabetes and related phenotypes J Clin Invest 114 1518-1526
[6]  
Eriksson KF(2004)Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins Diabetes 53 1385-1393
[7]  
Ek J(2003)Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes Dev Cell 5 73-83
[8]  
Andersen G(2005)Suppression of beta cell energy metabolism and insulin release by PGC-1alpha Diabetes 54 727-735
[9]  
Urhammer SA(2002)Functional and molecular defects of pancreatic islets in human type 2 diabetes Diabetes 51 S134-S137
[10]  
Barroso I(2001)Lipotoxicity in human pancreatic islets and the protective effect of metformin Mol Cell Endocrinol 175 57-66