The immune system and the impact of zinc during aging

被引：189
作者：
Haase H. [1 ]
Rink L. [1 ]
机构：
[1] Institute of Immunology, Medical Faculty, RWTH Aachen University, 52074 Aachen
来源：
Immunity & Ageing | / 6卷 / 1期
关键词：
Zinc; Zinc Deficiency; Zinc Level; Zinc Supplementation; Serum Zinc;
D O I：
10.1186/1742-4933-6-9
中图分类号：
学科分类号：
摘要：
The trace element zinc is essential for the immune system, and zinc deficiency affects multiple aspects of innate and adaptive immunity. There are remarkable parallels in the immunological changes during aging and zinc deficiency, including a reduction in the activity of the thymus and thymic hormones, a shift of the T helper cell balance toward T helper type 2 cells, decreased response to vaccination, and impaired functions of innate immune cells. Many studies confirm a decline of zinc levels with age. Most of these studies do not classify the majority of elderly as zinc deficient, but even marginal zinc deprivation can affect immune function. Consequently, oral zinc supplementation demonstrates the potential to improve immunity and efficiently downregulates chronic inflammatory responses in the elderly. These data indicate that a wide prevalence of marginal zinc deficiency in elderly people may contribute to immunosenescence. © 2009 Haase and Rink; licensee BioMed Central Ltd.
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