Hydroxyl radical-involved cancer therapy via Fenton reactions

被引：0
作者：
Mengying Liu
Yun Xu
Yanjun Zhao
Zheng Wang
Dunyun Shi
机构：
[1] Tianjin University,School of Pharmaceutical Science & Technology
[2] Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University,Central Lab
[3] Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University,Institute of Hematology
来源：
Frontiers of Chemical Science and Engineering | 2022年 / 16卷
关键词：
hydroxyl radical; Fenton catalyst; hydrogen peroxide; cancer therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The tumor microenvironment features over-expressed hydrogen peroxide (H2O2). Thus, versatile therapeutic strategies based on H2O2 as a reaction substrate to generate hydroxyl radical (•OH) have been used as a prospective therapeutic method to boost anticancer efficiency. However, the limited Fenton catalysts and insufficient endogenous H2O2 content in tumor sites greatly hinder •OH production, failing to achieve the desired therapeutic effect. Therefore, supplying Fenton catalysts and elevating H2O2 levels into cancer cells are effective strategies to improve •OH generation. These therapeutic strategies are systematically discussed in this review. Furthermore, the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed to improve therapeutic efficacy.
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页码：345 / 363
页数：18
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