Organ at risk dose measurements following radiotherapy treatment for breast cancer patients

被引：1
作者：
Duhaini I. [1 ]
Hodroj N. [2 ]
Farhat F. [3 ]
Ayoubi S. [2 ]
Maarouf A. [4 ]
Korek M. [1 ]
机构：
[1] Faculty of Science, Physics Department, Beirut Arab University, Beirut
[2] Radiation Oncology Department, Rafik Hariri University Hospital, Beirut
[3] Radiotherapy Department, Nabih Berry University Hospital, Nabateh
[4] Faculty of Medicine, Beirut Arab University, Beirut
来源：
Health and Technology | 2018年 / 8卷 / 5期
关键词：
Breast cancer; Probability of causation; Radiotherapy; Relative risk; Secondary cancer;
D O I：
10.1007/s12553-018-0254-2
中图分类号：
学科分类号：
摘要：
Radiotherapy technologies are one of the most common treatments for cancer, they have been successfully used to damage cancer cells, with as little harm as possible to nearby healthy cells, however Secondary cancer risk following radiotherapy is an increasingly important topic in clinical oncology with impact on treatment decision making and on patient management. The objective of this study is to measure the skin radiation dose received by the treated breast as well as the dose to the lungs in cancer patients undergoing breast radiotherapy and estimate the probability for radiation-induced cancer, i.e. secondary cancer and the probability of lung cancer. Usage of RANDO phantoms and GafChromic dosimetry films to do dose measurements during breast radiotherapy. Measured dose and calculated organ dose from patients were compared. The calculated doses were done using the effective dose formula. Measured point doses of both lungs were compared to those calculated by TPS (treatment planning system). Relative Risk (RR) and Probability of Causation (PC) of lungs- probability of cancer- were calculated from patient’s mean doses to the organs (right lung and left lung) using the model described in BEIR V report. RR mean values were 1.278 and 1.032 for ipsilateral and contralateral lungs respectively. In addition, PC mean values were 20.93 % and 3.099% for ipsilateral and contralateral lungs respectively. Breast cancer patients are susceptible to an increased risk of secondary cancer of ipsilateral lungs more than in the contralateral ones. © 2018, IUPESM and Springer-Verlag GmbH Germany, part of Springer Nature.
引用
收藏
页码：405 / 410
页数：5
相关论文
共 10 条
  • [1] Safora J., Dag R.O., Turi D., Erik M., Contralateral breast doses following radiotherapy of the breast andregional lymph nodes:Measurements and treatment planning calculations, The Gren Journal, 82, pp. 332-336, (2007)
  • [2] Berris T., Mazonakis M., Stratakis J., Tzedakis A., Fasoulaki A., Damilakis J., Calculation of organ doses from breast cancer radiotherapy: a Monte Carlo study, Journal of applied clinical physics, volume, 1, (2013)
  • [3] The 2007 Recommendations of the Iinternational Commission on Radiological Protection, Ann ICRP 2007, pp. 1-322, (2007)
  • [4] Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR Phase 2
  • [5] Suchowerska N., Hoban P., Butson M., Davison A., Metcalfe P., Directional dependence in film dosimetry: radiographic and radiochromic film, Physics in Medicine and Biology, 46, 5, pp. 1391-1397, (2001)
  • [6] Saveta M., Jean-Marc B., Francesco D., Roger H., Pawel O., Out-Of-Fiels Dose Measurements in Radiotherapy-An Overview of Activity of EURADOS Working Group 9: Radiation Protection in Medicine, pp. 270-275, (2014)
  • [7] Berrington de Gonzalez A., Curtis R.E., Gilbert E., Berg C.D., Smith S.A., Stovall M., Ron E., Second solid cancers after radiotherapy for breast cancer in SEER cancer registries, British Journal of Cancer, 102, 1, pp. 220-226, (2009)
  • [8] Vicini F., Kini V., Chen P., Horwitz E., Gustafson F., Benitez P., Edmundson G., Goldstein N., McCathry K., Martinez A., Irradiation of the tumor bed alone after lumpectomy in selected patients with early-stage breasst cancer treated with breast conserving radiotherapy, J Surg Oncol, 70, pp. 33-40, (1999)
  • [9] Amy B., Ethel G., Rochelle C., Peter I., Ruth K., Lindsay M., Preetha R., Mark P.L., Second solid cancers after radiotherapy: a systematic review of the epidemiological studies of the radiation dose-response relationship, International Journal of Radiation Oncology Biology Physics, 86, 2, pp. 224-233, (2013)
  • [10] Neugut A., Murray T., Santos J., Amols H., Hayes M., Flannery J., Robinson E., Increased risk of lung cancer after breast radiotherapy in cegarrette smokers, Cancer, 73, pp. 1615-1620, (2006)
1