MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells

被引：0
作者：
Zheng-ming Wang
Wen-jun Du
Gary A Piazza
Yaguang Xi
机构：
[1] Mitchell Cancer Institute,
[2] University of South Alabama,undefined
[3] Ji-nan Infectious Disease Hospital,undefined
来源：
Acta Pharmacologica Sinica | 2013年 / 34卷
关键词：
cancer; stem cells; miRNAs; tumorigenesis; tumor progression; self-renewal; differentiation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNAs (miRNAs) are small non-coding RNA molecules, whose primary function is to regulate gene expression at the post-transcriptional/translational levels. MiRNAs play crucial roles in normal biological processes and are commonly dys-regulated in human diseases. Stem cells are regarded as the “mother” cells of all types of differentiated cells that comprise tissues and organs of the body. A novel hypothesis proposes that tumors are composed of heterogeneous cells derived from cancer stem cells, which have self-renewal and differentiation capabilities similar to those of normal stem cells. Cancer stem cells have been isolated and characterized from various tumors. Given recent studies supporting the critical regulatory roles of miRNAs in the self-renewal and differentiation of cancer stem cells, better understanding the functions of miRNAs will provide invaluable insights into the prevention of tumorigenesis and tumor progression. In this review, we will summarize the research progress in the study of miRNAs involved in the self-renewal and differentiation of cancer stem cells.
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页码：1374 / 1380
页数：6
相关论文
共 377 条
[11]  
Liu S(2004)Nuclear export of microRNA precursors Science 303 95-8
[12]  
Dontu G(2004)Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs RNA 10 185-91
[13]  
Bonnet D(2001)Role for a bidentate ribonuclease in the initiation step of RNA interference Nature 409 363-6
[14]  
Dick JE(2001)Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control Cell 106 23-34
[15]  
Visvader JE(2001) developmental timing Science 293 834-8
[16]  
Lindeman GJ(2001)A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA Genes Dev 15 2654-9
[17]  
Ambros V(2001)Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in Science 293 2269-71
[18]  
Bartel DP(2002)A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Genes Dev 16 720-8
[19]  
Lee Y(2006)miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs Genes Dev 20 515-24
[20]  
Kim M(2011)Control of translation and mRNA degradation by miRNAs and siRNAs Cancer Res 71 5950-4
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