Synthesis and characterization of inclusion complex of the vasodilator drug minoxidil with β-cyclodextrin

被引：0
|
作者：
A. Calderini
F. B. T. Pessine
机构：
[1] Institute of Chemistry,
[2] UNICAMP,undefined
来源：
Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2008年 / 60卷
关键词：
Minoxidil; β-Cyclodextrin; Inclusion complex; NMR; ROESY; DOSY;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The inclusion complex of β-cyclodextrin and minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was synthesized using two methods—kneading and freeze-drying—and characterized by UV-Vis spectroscopy, infrared spectroscopy, powder X-ray diffractometry, differential scanning calorimetry, thermal gravimetric analysis, and nuclear magnetic resonance spectroscopy. These techniques have demonstrated the existence of inclusion compound formation between the host and guest with a molar ratio of 1:1. The studies of solubility and the data obtained by nuclear magnetic resonance spectroscopy showed a weak interaction between the guest and the cyclodextrin molecules in solution.
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页码：369 / 377
页数：8
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