Biocompatibility of a polymer patch for rotator cuff repair

被引:0
作者
Brian J. Cole
Andreas H. Gomoll
Adam Yanke
Tamara Pylawka
Paul Lewis
John D. MacGillivray
James M. Williams
机构
[1] Rush University Medical Center,Department of Orthopedics and Anatomy and Cell Biology
[2] Rush Medical College,Department of Orthopedic Surgery
[3] Brigham and Women’s Hospital,Department of Orthopedic Surgery
[4] Harvard Medical School,Department of Anatomy
[5] Hospital for Special Surgery,undefined
[6] Rush University Medical Center,undefined
[7] Rush Medical College,undefined
来源
Knee Surgery, Sports Traumatology, Arthroscopy | 2007年 / 15卷
关键词
Rotator cuff; Animal model; Biocompatible material;
D O I
暂无
中图分类号
学科分类号
摘要
Both mechanical and biological factors influence the high re-tear rate after rotator cuff repair. Mechanical factors have largely been addressed by the introduction of better implants and modification of suture configuration, but further improvements are needed to address the often poor tissue quality of the degenerated rotator cuff tendons. Current biological solutions provide only short-term reinforcement and have been associated with pseudo-infectious reactions. This pre-clinical animal study investigates the biological response to a novel polycarbonate polyurethane patch used for tissue augmentation in a rat rotator cuff repair model. Bilateral defects were created in the supraspinatus tendons of 12 Sprague Dawley rats. One side was repaired with a patch as a tissue augmentation device. The contralateral side acted as internal control without patch augmentation. After 6 weeks the tissues were harvested and underwent histologic and histomorphometric analyses. Histological evaluation demonstrated no inflammatory reaction; histomorphometry revealed tissue ingrowth of 79.9%. In conclusion, the polycarbonate polyurethane patch for tissue extension or augmentation in rotator cuff repair has demonstrated no inflammatory response and excellent tissue integration in a rat rotator cuff repair model.
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页码:632 / 637
页数:5
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