Bioactive effects of olive oil phenolic compounds in humans: Reduction of heart disease factors and oxidative damage

被引:86
作者
Covas M.-I. [1 ]
机构
[1] Cardiovascular Risk and Nutrition Group, Institut Municipal d'Investigació Mèdica (IMIM-Hospital del Mar), CIBER de Fisiopatología de la Obesidad Y Nutrición, Barcelona 08003, Carrer Doctor Aiguader
关键词
Antioxidants; DNA oxidation; LDL oxidation; Olive oil; Polyphenols;
D O I
10.1007/s10787-008-8019-6
中图分类号
学科分类号
摘要
Oxidative stress is defined as an imbalance between the oxidant and antioxidant systems of the body, in favour of the oxidants. Oxidative stress produced by free radicals has been linked to the development of several diseases such as cardiovascular, cancer, and neurodegenerative diseases. Olive oil is the main source of fat of the Mediterranean diet which has been shown to be effective against oxidative stress associated diseases and also with the ageing. Besides its richness in monounsaturated fatty acid, the oleic acid, olive oil contains minor components with antioxidant properties. Here, we update the state of the art, and degree of evidence, of the body of knowledge concerning the protective role on lipids and lipid oxidative damage in humans of the olive oil phenolic compounds. © 2008 Birkhäuser Verlag.
引用
收藏
页码:216 / 218
页数:2
相关论文
共 25 条
[1]  
Aviram M., Interaction of oxidized low density lipoprotein with macrophages in atherosclerosis, and the antiatherogenicity of antioxidants, Eur. J. Clin. Chem. Clin. Biochem, 34, pp. 599-608, (1996)
[2]  
Cooke M.S., Evans M.D., Dizdaroglu, Et al., Oxidative DNA damage: Mechanisms, mutation, and disease, FASEB, 17, pp. 1195-1214, (2003)
[3]  
Covas M.I., Nyyssonen K., Poulsen H.E., Et al., The effect of polyphenols in olive oil on heart disease risk factors, Ann. Int. Med, 145, pp. 333-341, (2006)
[4]  
Covas M.I., Ruiz-Gutierrez V., De la Torre R., Et al., Minor components of olive Oil: Evidence to date of health benefits in humans, Nutr. Rev, 64, pp. 20-30, (2006)
[5]  
Evans M.D., Dizdaroglu M., Cooke M.S., Et al., Oxidative DNA damage and disease: Induction, repair and significance, Mutat. Res, 567, pp. 1-61, (2004)
[6]  
Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), JAMA, 285, pp. 2486-2697, (2001)
[7]  
Fito M., De la Torre R., Covas M.I., Olive oil and oxidative stress, Mol. Nutr. Food. Rev, 51, pp. 1215-1224, (2007)
[8]  
Fogelman A.M., When good cholesterol goes bad, Nature Med, 10, pp. 902-903, (2004)
[9]  
November 1. Accessed on, (2008)
[10]  
Gimeno E., Castellote A.I., Lamuela-Raventos R.M., Et al., The effect of harvest and extraction methods on the antioxidant content (phenolics, ?-tocopherol, and ?-carotene) in virgin olive oil, Food Chem, 78, pp. 207-211, (2002)