Emerging beneficial roles of sirtuins in heart failure

被引：0
作者：
Masaya Tanno
Atsushi Kuno
Yoshiyuki Horio
Tetsuji Miura
机构：
[1] Sapporo Medical University,Second Department of Internal Medicine
[2] Sapporo Medical University,Department of Pharmacology
来源：
Basic Research in Cardiology | 2012年 / 107卷
关键词：
SIRT1; SIRT3; Heart failure; Mitochondria; Metabolism; Oxidative stress;
D O I：
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摘要：
Sirtuins are a highly conserved family of histone/protein deacetylases whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. In mammalian cells, seven sirtuins (SIRT1–7) modulate distinct metabolic and stress-response pathways, SIRT1 and SIRT3 having been most extensively investigated in the cardiovascular system. SIRT1 and SIRT3 are mainly located in the nuclei and mitochondria, respectively. They participate in biological functions related to development of heart failure, including regulation of energy production, oxidative stress, intracellular signaling, angiogenesis, autophagy and cell death/survival. Emerging evidence indicates that the two sirtuins play protective roles in failing hearts. Here, we summarize current knowledge of sirtuin functions in the heart and discuss its translation into therapy for heart failure.
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