Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

被引：0
作者：
Pranav Preman
Julia TCW
Sara Calafate
An Snellinx
Maria Alfonso-Triguero
Nikky Corthout
Sebastian Munck
Dietmar Rudolf Thal
Alison M Goate
Bart De Strooper
Amaia M Arranz
机构：
[1] VIB Center for Brain & Disease Research,Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI)
[2] KU Leuven (University of Leuven),Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology
[3] Icahn School of Medicine at Mount Sinai,Department of Neuroscience & Friedman Brain Institute
[4] Icahn School of Medicine at Mount Sinai,Ronald M. Loeb Center for Alzheimer’s disease
[5] Icahn School of Medicine at Mount Sinai,Department of Neurosciences
[6] Achucarro Basque Center for Neuroscience,Laboratory for Neuropathology, Department of Imaging and Pathology, Leuven Brain Institute (LBI), Department of Pathology
[7] Universidad del País Vasco (UPV/EHU),Dementia Research Institute
[8] VIB Bio Imaging Core,undefined
[9] KU Leuven (University of Leuven),undefined
[10] University Hospital Leuven,undefined
[11] University College London,undefined
[12] Ikerbasque Basque Foundation for Science,undefined
来源：
Molecular Neurodegeneration | / 16卷
关键词：
Human induced pluripotent stem cells (hiPSCs); Astrocytes; Chimeric mouse models; Alzheimer’s disease; Amyloid plaques; Apolipoprotein E (; );
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 581 条
[1]  
Ferrer I(2018)Astrogliopathy in Tauopathies Neuroglia 1 126-50
[2]  
Verkhratsky A(2018)Physiology of Astroglia Physiol Rev 98 239-389
[3]  
Nedergaard M(2017)Neurotoxic reactive astrocytes are induced by activated microglia Nature 541 481-7
[4]  
Liddelow SA(2018)NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS EMBO J 37 e98697-8
[5]  
Guttenplan KA(2018)Microglial control of astrocytes in response to microbial metabolites Nature 557 724-8
[6]  
Clarke LE(2018)Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson ’ s disease Nat Med 24 931-9
[7]  
Bennett FC(2020)MAFG-driven astrocytes promote CNS inflammation Nature 578 593-14
[8]  
Bohlen CJ(2019)The role of astroglia in Alzheimer’s disease: pathophysiology and clinical implications Lancet Neurol 18 406-72
[9]  
Schirmer L(2018)Astrocytic degeneration in chronic traumatic encephalopathy Acta Neuropathol 136 955-9
[10]  
Bennett ML(1995)Early association of reactive astrocytes with senile plaques in Alzheimer’s disease Exp Neurol 132 172-42
12345678910