The importance of ubiquitination and sumoylation on the transforming activity of HTLV Tax-1 and Tax-2

被引：0
作者：
Linda Zane
Kuan-Teh Jeang
机构：
[1] the National Institutes of Health,Molecular Virology Section, Laboratory of Molecular Microbiology, the National Institutes of Allergy and Infectious Diseases
来源：
Retrovirology | / 9卷
关键词：
HTLV-1; HTLV-2; Tax; ATL; Cell transformation; NF-κB; Sumoylation; Ubiquitination;
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摘要：
Human T-cell Leukemia Virus type 1 (HTLV-1) and 2 (HTLV-2) are two closely related human retroviruses. HTLV-1 is associated with an aggressive Adult T-cell Leukemia (ATL) while there is no evidence for an association of HTLV-2 with any human malignancies. The two viruses encode transactivator proteins, Tax-1 and Tax-2 respectively. In ATL, Tax-1 is thought to play a central role in the transformation of a normal T-cell into a leukemic cell; however, it has not been entirely clear how post-translational modifications of Tax-1 influence its transforming activity. Here, we discuss three recent papers that report on the ubiquitination and sumoylation of Tax-1 and Tax-2. We comment on their divergent findings implicating the importance (or lack of importance) of these modifications and other events on Tax activation of NF-κB as related to cellular transformation.
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