The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers

被引：0
作者：
Luisina De Tullio
Bruno Maggio
Steffen Hartel
Jorge Jara
Maria Laura Fanani
机构：
[1] Universidad Nacional de Córdoba,Departamento de Química Biológica – Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Facultad de Ciencias Químicas – CONICET
[2] Universidad de Chile,Anatomy and Development Biology Program, ICBM Faculty of Medicine
[3] Universidad Austral de Chile,Centro de Estudios Científicos CECS
来源：
Cell Biochemistry and Biophysics | 2007年 / 47卷
关键词：
Phospholipid monolayers; Sphingomyelinase; Epifluorescence microscopy; Sphingomyelin; Ceramide; Phase coexistence; Laterally segregated domains;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Changes of the initial composition and topography of mixed monolayers of Sphingomyelin and Ceramide modulate the degradation of Sphingomyelin by Bacillus cereus Sphingomyelinase. The presence of initial lateral phase boundary due to coexisting condensed and expanded phase domains favors the precatalytic steps of the reaction. The amount and quality of the domain lateral interface, defined by the type of boundary undulation, appears as a modulatory supramolecular code which regulates the catalytic efficiency of the enzyme. The long range domain lattice structuring is determined by the Sphingomyelinase activity.
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页码：169 / 177
页数：8
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