Roles of ferritin and iron in ischemic preconditioning of the heart

被引:0
作者
Eduard Berenshtein
Boris Vaisman
Chaya Goldberg-Langerman
Nahum Kitrossky
Abraham M. Konijn
Mordechai Chevion
机构
[1] The Hebrew University-Hadassah Schools of Medicine and Dental Medicine,Department of Cellular Biochemistry and Human Genetics
[2] The Hebrew University-Hadassah Schools of Medicine and Dental Medicine,Department of Human Nutrition and Metabolism
来源
Molecular and Cellular Biochemistry | 2002年 / 234-235卷
关键词
heart protection; preconditioning; ischemia; iron; ferritin; reperfusion injury; isolated rat heart; free radicals;
D O I
暂无
中图分类号
学科分类号
摘要
Iron and copper play major roles in biological systems, catalyzing free radical production and consequently causing damage. The relatively high levels of these metals, which are mobilized into the coronary flow following prolonged ischemia, have been incriminated as key players in reperfusion injury to the heart. In the present communication we investigated other roles of iron – providing protection to the ischemic heart via preconditioning (PC).
引用
收藏
页码:283 / 292
页数:9
相关论文
共 161 条
  • [1] De Jong JW(2000)The role of adenosine in preconditioning Pharmacol Ther 87 141-149
  • [2] de Jonge R(2000)Ischemic preconditioning: From basic mechanisms to clinical applications Pharmacol Ther 86 263-275
  • [3] Keijzer E(1999)Ischemic preconditioning in humans: Models, mediators, and clinical relevance Circulation 100 559-563
  • [4] Bradamante S(1999)Oxygen free radical signaling in ischemic preconditioning Ann NY Acad Sci 30 49-65
  • [5] Nakano A(1999)Cellular mechanisms of infarct size reduction with ischemic preconditioning. Role of calcium? Ann NY Acad Sci 30 192-210
  • [6] Cohen MV(2001)Menadione mimics the infarct-limiting effect of preconditioning in isolated rat hearts Am J Physiol Heart Circ Physiol 281 H590-H595
  • [7] Downey JM(1992)Iron chelation in myocardial preservation after ischemia-reperfusion injury: The importance of pretreatment and toxicity Ann Thorac Surg 53 412-418
  • [8] Tomai F(1997)Nitroxide radicals prevent metal-aggravated reperfusion injury in isolated rat heart Free Radic Res Commun 27 627-635
  • [9] Crea F(1993)Copper and iron are mobilized following myocardial ischemia: Possible predictive criteria for tissue injury Proc Natl Acad Sci USA 90 1102-1106
  • [10] Chiariello L(1997)Patterns of mobilization of copper and iron following myocardial ischemia: Pos-291 sible predictive criteria for tissue injury J Mol Cell Cardiol 29 3025-3034