A new gene-based association test for genome-wide association studies

被引：0
作者：
Alfonso Buil
Angel Martinez-Perez
Alexandre Perera-Lluna
Leonor Rib
Pere Caminal
Jose Manuel Soria
机构：
[1] Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau,Unitat de Genomica de Malalties Complexes
[2] Universitat Politecnica de Catalunya,Centre de Recerca en Enginyeria Biomedica, Departament d'Enginyeria Sistemes i Automatica Industrial
来源：
BMC Proceedings | / 3卷 / Suppl 7期
关键词：
Rheumatoid Arthritis; Cluster Algorithm; Spectral Cluster; Ancestral Haplotype; Rheumatoid Arthritis Susceptibility;
D O I：
10.1186/1753-6561-3-S7-S130
中图分类号：
学科分类号：
摘要：
Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex diseases. Usually, these methods work in a SNP-by-SNP fashion. We present a gene-based test that can be applied in the context of genome-wide association studies. We compare both strategies, SNP-based and gene-based, in a sample of cases and controls for rheumatoid arthritis.
引用
收藏
相关论文
共 211 条
[1]  
Neale BM(2004)The future of association studies: gene-based analysis and replication Am J Hum Genet 75 353-362
[2]  
Sham PC(2000)Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins Arthritis Rheum 43 30-37
[3]  
MacGregor AJ(1994)HLA-linked rheumatoid arthritis Am J Hum Genet 55 738-746
[4]  
Snieder H(2004)A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis Am J Hum Genet 75 330-337
[5]  
Rigby AS(2007)TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study N Engl J Med 357 1199-1209
[6]  
Koskenvuo M(2007)STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus N Engl J Med 357 977-986
[7]  
Kaprio J(2008)Common variants at CD40 and other loci confer risk of rheumatoid arthritis Nat Genet 40 1216-1223
[8]  
Aho K(2008)A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2 PLoS Genet 4 e1000107-1296
[9]  
Silman AJ(2009)Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data BMC Proc 3 S2-126
[10]  
Hasstedt SJ(2007)GenABEL: an R library for genome-wide association analysis Bioinformatics 23 1294-637
12345678910