Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

被引：0
|
作者：
Irfan A. Asangani
Vijaya L. Dommeti
Xiaoju Wang
Rohit Malik
Marcin Cieslik
Rendong Yang
June Escara-Wilke
Kari Wilder-Romans
Sudheer Dhanireddy
Carl Engelke
Mathew K. Iyer
Xiaojun Jing
Yi-Mi Wu
Xuhong Cao
Zhaohui S. Qin
Shaomeng Wang
Felix Y. Feng
Arul M. Chinnaiyan
机构：
[1] Michigan Center for Translational Pathology,Department of Pathology
[2] University of Michigan Medical School,Department of Biostatistics and Bioinformatics
[3] University of Michigan Medical School,Department of Radiation Oncology
[4] Emory University,Departments of Internal Medicine
[5] University of Michigan Medical School,Department of Urology
[6] Howard Hughes Medical Institute,undefined
[7] University of Michigan Medical School,undefined
[8] Pharmacology,undefined
[9] and Medicinal Chemistry,undefined
[10] University of Michigan Medical School,undefined
[11] Comprehensive Cancer Center,undefined
[12] University of Michigan Medical School,undefined
[13] University of Michigan Medical School,undefined
来源：
Nature | 2014年 / 510卷
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学科分类号：
摘要：
Small-molecule compounds that target the BET domain in proteins such as BRD4 have recently been identified as potential anticancer agents; here, the efficacy of the BRD4-targeting compound JQ1 is demonstrated in castration-resistant prostate cancer driven by deregulated androgen receptor action.
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页码：278 / 282
页数：4
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